Activities
The Prescription Sequence Symmetry Analysis (PSSA) Study 1: Association between antipsychotic use and diabetes. Objective: To test the feasibility of using a distributed model for undertaking studies in AsPEN. Design: A distributed network model was employed using fit for purpose code written by the University of South Australia to test the association between antipsychotic use […]
The Prescription Sequence Symmetry Analysis (PSSA) Study 2: Association between thiazolidinediones and cardiovascular diseases. Objective: To test the risk of cardiovascular disease from thiazolidinediones across AsPEN countries. Method: Pharmacogenetic differences between Asian and Caucasian populations led to a hypothesis that the adverse cardiovascular events of thiazolidinediones may be less common in Asian populations than Caucasian […]
The Prescription Sequence Symmetry Analysis (PSSA) Study 3: Prescription Symmetry: A validation study Objective: To test the validity of PSSA in identifying one positive and two negative controls across multiple data sets from different countries. Method: The positive control was amiodarone and thyroxine. Amiodarone is known to cause hypothyroidism. The negative controls were 1) amiodarone […]
The Prescription Sequence Symmetry Analysis (PSSA) Study 4: Association between proton pump inhibitor use and clostridium difficile infections Objective: To test the risk of treatment for clostridium difficile from proton pump inhibitors across AsPEN countries and Canada. Method: Health Canada had a hypothesis that proton pump inhibitors may contribute to clostridium difficile infections. Australia (two […]
Comparative Safety of Nonsteroidal Anti-inflammatory Drugs Commonly Used in Asia Background: Some nonsteroidal anti-inflammatory drugs (NSAIDs) are only or more commonly used in Asian countries (i.e., loxoprofen, mefenamic acid) and their safety has not been well-studied. Objectives: To compare the risk of major safety events among initiators of 4 NSAIDs which are commonly used in […]
Surveillance of Health Care in Asian Network (SCAN) Project: Infrastructure Development and Analysis with the Asian Pharmacoepidemiology Network Background To date, the initiative has included two tracks of postmarketing surveillance activities, one using a simple signal detection method and a more formal pharmacoepidemiological study to validate or confirm a signal. Currently, the administrative office for […]
Databases in Asia: The Potential for Distributed Network Approach *Note: If you are interested and would like to participate in this study, you can click following link: https://duke.qualtrics.com/SE/?SID=SV_a8A9e8o4iASh8pf to start the survey Background: Pharmacoepidemiology in Asia Pharmacoepidemiology (PE) studies provide evidence on beneficial and adverse effects of medical products in real world populations and practice […]
